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Protein in human blood platelets points to a new weapon against malaria

One of the world's most devastating diseases is   malaria , responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe. Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets. "We eventually found that a single...

Protein in human blood platelets points to a new weapon against malaria

One of the world's most devastating diseases is   malaria , responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe. Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets. "We eventually found that a single...

POSTPARTUM HEMORRHAGE

Postpartum Hemorrhage Postpartum hemorrhage is blood loss of > 500 mL during or immediately after the 3rd stage of labor in a vaginal delivery or > 1000 mL in a cesarean delivery. Diagnosis is clinical. Treatment depends on etiology of the hemorrhage. Causes of postpartum hemorrhage : > Uterine atony (the most common) > Lacerations of the genital tract > Extension of an episiotomy > Uterine rupture > Bleeding disorders > Retained placental tissues > Hematoma > Uterine inversion >Subinvolution (incomplete involution) of the placental site (which usually occurs early but may occur as late as 1 mo after delivery) Risk factors for uterine atony include uterine overdistention (caused by multifetal pregnancy, polyhydramnios, or an abnormally large fetus), prolonged or dysfunctional labor, grand multiparity (delivery of ≥ 5 viable fetuses), relaxant anesthetics, rapid labor, and chorioamnionitis. Uterine fibroids may contribute to postpartum hemorrhage. A hi...

Oral Contraceptive Pills : Uses , Fuctions, Toxic Syndrommes..........

Oral cotraceptive pills are tablets that prevents conception. Perhaps its the most accepted contraceptive method in developing countries. Its principle function is to prevent conception and it doesn't give any protection against HIV and other STD's. Oral Contraceptive Pills (OCP) are mainly two types. 1. Combiled OCP. 2. Progesteron OR Estrogen only Pills. The mechanism of action of OCP is very simple. We know that female Menstrual cycle is devided into three phases. 1. Proliferative phase : Here estrogen is secreted by Ovary , which causes uterine endrometrial growth. After this phase there is sudden withdrwal af estrogen which causes Ovulation ( It is the fall of mature ovum into Peritoneal Cavity , which ultimately comes into the uterine tube and finally in uterus ). 2. Secretory phase : Here both Progesterone and Estrogen Causes more and more growth if endometrium and increase secretion by the uterine glands. 3. The Menstrual phase : Here sudden Withdrawal of Progesterone ...

Overweight and Its Relation to CHD

UNDERSTANDING CORONARY HEART DISEASE (CHD) According to current estimates, 64.4 million Americans have one or more types of cardiovascular disease. Within cardiovascular diseases, coronary heart disease (CHD) is the single largest killer of Americans. CHD caused 502,189 deaths in the US in 2001 – about 1 in every 5. The American Heart Association estimates that 13.2 million Americans have CHD. In fact, up to half of all sudden, out-of-hospital cardiac deaths occur in people with no prior diagnosis of heart disease, and over two-thirds of heart attach sufferers have blockages in their arteries considered to be clinically “insignificant” in terms of plaque burden and percent stenosis. Until recently, it was widely held that most heart attacks were caused by a gradual build-up of atherosclerotic plaque within the arteries of the heart (“hardening of the arteries”), impedes blood flow, and eventually results in blocked blood vessels that can cause acute ischemic events such as...
Research 06 : Diabetes Can Be Cured Parmanantly. Diabetes Mellitus ..... Its a very common name for some peoples of this world. Because its on the diseases that is also called a " silent killer ". But proper care can relives its symptoms. Let us Know what is Diabetes Mellitus (DM). Simply its a disease of Pancreatic B- Cells where there is less production of Insulin. As a result , blood glucose is not properly metabolised. So, there is extra amount of blood glucose which causes several symptoms.  Now , DM is a great challenge to treat. Now a days one in every 300 aged person has Insulin Dependant Type-I Diabetes (IDDM-I) . So redical cure of it can save thousands of People. Still today the only prophylaxis that causes symptomatic releive is Controlling DM. But, Researchers have reached beyond the limit. Experiment of Animals like Rat , shows that a B-Celll transplantation can prodeces sufficient amount of Insulin . And its sufficient to meet the peripheral demand of Insulin i...