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Liver Stem Cells Discovered in Mice Share on email Share on facebook Share on twitter Scientists successfully identified and grew a renewable population of liver stem cells for the first time, a new study reported. Tissues derived from these stem cells slightly boosted liver function when implanted into mice with a liver disorder. The findings could eventually lead to approaches that help rejuvenate damaged livers in people. A single cell was coaxed to mature into liver cells that produce common liver proteins (green and red).  Image courtesy of Huch et al.,  Nature . The liver is a large, versatile organ that has many jobs, including cleansing blood and digesting food. The liver also has a unique ability to quickly regenerate and regain its original size if partially removed by surgery. Scientists have long known that stem cells that have the potential to create more liver cells must exist in the adult liver. But until now, no one had found a way to detect a...

Protein in human blood platelets points to a new weapon against malaria

One of the world's most devastating diseases is   malaria , responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe. Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets. "We eventually found that a single...

Protein in human blood platelets points to a new weapon against malaria

One of the world's most devastating diseases is   malaria , responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe. Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets. "We eventually found that a single...

POSTPARTUM HEMORRHAGE

Postpartum Hemorrhage Postpartum hemorrhage is blood loss of > 500 mL during or immediately after the 3rd stage of labor in a vaginal delivery or > 1000 mL in a cesarean delivery. Diagnosis is clinical. Treatment depends on etiology of the hemorrhage. Causes of postpartum hemorrhage : > Uterine atony (the most common) > Lacerations of the genital tract > Extension of an episiotomy > Uterine rupture > Bleeding disorders > Retained placental tissues > Hematoma > Uterine inversion >Subinvolution (incomplete involution) of the placental site (which usually occurs early but may occur as late as 1 mo after delivery) Risk factors for uterine atony include uterine overdistention (caused by multifetal pregnancy, polyhydramnios, or an abnormally large fetus), prolonged or dysfunctional labor, grand multiparity (delivery of ≥ 5 viable fetuses), relaxant anesthetics, rapid labor, and chorioamnionitis. Uterine fibroids may contribute to postpartum hemorrhage. A hi...

Oral Contraceptive Pills : Uses , Fuctions, Toxic Syndrommes..........

Oral cotraceptive pills are tablets that prevents conception. Perhaps its the most accepted contraceptive method in developing countries. Its principle function is to prevent conception and it doesn't give any protection against HIV and other STD's. Oral Contraceptive Pills (OCP) are mainly two types. 1. Combiled OCP. 2. Progesteron OR Estrogen only Pills. The mechanism of action of OCP is very simple. We know that female Menstrual cycle is devided into three phases. 1. Proliferative phase : Here estrogen is secreted by Ovary , which causes uterine endrometrial growth. After this phase there is sudden withdrwal af estrogen which causes Ovulation ( It is the fall of mature ovum into Peritoneal Cavity , which ultimately comes into the uterine tube and finally in uterus ). 2. Secretory phase : Here both Progesterone and Estrogen Causes more and more growth if endometrium and increase secretion by the uterine glands. 3. The Menstrual phase : Here sudden Withdrawal of Progesterone ...